Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INPPL1 | O15357 | 6/20 | 0.46 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.43 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3145280 | 0.86 | CHRNB1 (0.49) | INPPL1CHRNB1CHRNB2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL3151937 | 0.85 | CHRNB1 (0.48) | INPPL1CHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL3147306 | 0.83 | INPPL1 (0.43) | INPPL1CHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL3137034 | 0.83 | INPPL1 (0.41) | INPPL1CHRNB1CHRNB2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL3781503 | 0.82 | LRRK2 (0.37) | INPPL1CHRNB4CHRNA3LRRK2 | |
| SCHEMBL3143138 | 0.82 | INPPL1 (0.39) | INPPL1LRRK2 | |
| SCHEMBL3137171 | 0.80 | CHRNB1 (0.36) | INPPL1CHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL3145422 | 0.80 | INPPL1 (0.43) | INPPL1CHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL3145479 | 0.80 | CHRNB2 (0.51) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3147229 | 0.79 | CHRNB2 (0.49) | INPPL1CHRNB1CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |