Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INPPL1 | O15357 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.37 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3145280 | 0.88 | CHRNB1 (0.49) | INPPL1CHRNB2CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL3147306 | 0.88 | INPPL1 (0.43) | INPPL1CHRNB2CHRNB1CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL3151937 | 0.87 | CHRNB1 (0.48) | INPPL1CHRNB2CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL3143138 | 0.84 | INPPL1 (0.39) | INPPL1 | |
| SCHEMBL3147229 | 0.83 | CHRNB2 (0.49) | INPPL1CHRNB2CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL3150890 | 0.83 | INPPL1 (0.46) | INPPL1CHRNB2CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL3141790 | 0.82 | CHRNB2 (0.48) | INPPL1CHRNB2CHRNB1CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL3765553 | 0.82 | CHRNB2 (0.48) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL3150832 | 0.81 | ACVR1B (0.40) | CYP1A1CYP1B1 | |
| SCHEMBL3150922 | 0.81 | CHRNB1 (0.49) | INPPL1CHRNB2CHRNB1CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |