SCHEMBL31526151

SCHEMBL31526151

Cc1noc(-c2ccccc2)c1CSC[C@H]1O[C@@H](n2cc(CC(C)C)c3c(N)ncnc32)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.35

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 4/20 0.35
▸ PRMT9 Q6P2P2 1/20 0.35
▸ ADK P55263 2/20 0.33
▸ DOT1L Q8TEK3 4/20 0.32
▸ PRMT3 O60678 2/20 0.32
▸ DNMT1 P26358 2/20 0.32
▸ NNMT P40261 1/20 0.32
▸ RET P07949 1/20 0.31
▸ EHMT2 Q96KQ7 1/20 0.31
▸ NADK O95544 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31526088 0.91 ADK (0.36) PRMT5PRMT9ADKDOT1LPRMT3
SCHEMBL31526204 0.90 PRMT5 (0.35) PRMT5PRMT9ADKDOT1LPRMT3
SCHEMBL31526128 0.90 ADK (0.33) PRMT5PRMT9ADKDOT1LPRMT3
SCHEMBL31526181 0.89 ADK (0.41) PRMT5PRMT9ADKDOT1LPRMT3
SCHEMBL31526211 0.89 DOT1L (0.33) PRMT5PRMT9ADKDOT1LPRMT3
SCHEMBL31526254 0.89 PRMT5 (0.41) PRMT5PRMT9ADK
SCHEMBL31526198 0.87 PRMT5 (0.34) PRMT5PRMT9ADKDOT1LPRMT3
SCHEMBL31526221 0.87 PRMT5 (0.34) PRMT5PRMT9ADKDOT1LPRMT3
SCHEMBL31526233 0.87 DOT1L (0.43) PRMT5PRMT9ADKDOT1LPRMT3
SCHEMBL31570705 0.87 GNMT (0.39) PRMT5PRMT9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025098545-A1 NUCLEOSIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST CORONAVIRUSES USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I. (CZ) 2025-05-15 — — WO disclosed
EP-4553080-A1 NUCLEOSIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST CORONAVIRUSES Ustav Organicke Chemie a Biochemie AV CR, v.v.i. (CZ) 2025-05-14 — — EP disclosed
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