Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | DRD3 | P35462 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3153025 | 0.83 | ADRA1A (0.46) | ADRA1ADRD2DRD3GAAGFER | |
| Hydrochloric Acid SCHEMBL2337988 | 0.82 | ADRA1A (0.45) | ADRA1ADRD2DRD3GAAGFER | |
| SCHEMBL3156539 | 0.80 | POLB (0.37) | DRD2DRD3HTR2A | |
| Hydrochloric Acid SCHEMBL3156540 | 0.78 | HTR1A (0.49) | ADRA1ADRD2DRD3HTR1AHTR7 | |
| SCHEMBL3156522 | 0.77 | HTR1A (0.45) | ADRA1ADRD2DRD3HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL3154721 | 0.76 | HTR1A (0.54) | ADRA1ADRD2DRD3ALDH1A1L3MBTL1 | |
| SCHEMBL3153019 | 0.75 | HTR1A (0.49) | DRD2GAAGFERALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL3152877 | 0.74 | HTR1A (0.46) | ADRA1ADRD2DRD3HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL3143011 | 0.74 | HTR1A (0.46) | ADRA1ADRD2DRD3HTR1AHTR2A | |
| SCHEMBL11155348 | 0.73 | KCNH2 (0.67) | DRD2HTR1AHTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075976-A1 | SUBSTITUTED PIPERAZINYL PYRAZINES AND PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075976-A1 | SUBSTITUTED PIPERAZINYL PYRAZINES AND PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | HTR7, HTR1A, HTR2C | ADRA1A 293/4885DRD2 319/4885DRD3 389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.