Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27874051 | 0.79 | DRD2 (0.45) | HTR1AGAAGFERALDH1A1L3MBTL1 | |
| SCHEMBL8343540 | 0.79 | HTR1A (0.65) | HTR1AALDH1A1HTR7DRD2HTR2A | |
| SCHEMBL3156525 | 0.77 | HTR1A (0.48) | HTR1AHTR7DRD2HTR2A | |
| Hydrochloric Acid SCHEMBL3156545 | 0.77 | HTR1A (0.54) | HTR1AALDH1A1HTR7DRD2HTR2A | |
| SCHEMBL27874050 | 0.77 | GAA (0.40) | HTR1AGAAGFERALDH1A1L3MBTL1 | |
| SCHEMBL3153025 | 0.76 | ADRA1A (0.46) | HTR1AGAAGFERALDH1A1L3MBTL1 | |
| SCHEMBL3153010 | 0.75 | ADRA1A (0.45) | HTR1AGAAGFERALDH1A1L3MBTL1 | |
| SCHEMBL6961329 | 0.75 | NPC1 (0.60) | HTR1AALDH1A1L3MBTL1HTR7 | |
| SCHEMBL3436467 | 0.75 | OPRM1 (0.55) | HTR1AALDH1A1HTR7DRD2DRD4 | |
| SCHEMBL1867299 | 0.75 | CACNA1G (0.65) | HTR1AHTR7DRD2HTR2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075976-A1 | SUBSTITUTED PIPERAZINYL PYRAZINES AND PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075976-A1 | SUBSTITUTED PIPERAZINYL PYRAZINES AND PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | HTR7, HTR1A, HTR2C | HTR1A 2/4885GAA 4885/4885GFER 2974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.