Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31532055 | 0.79 | SIK2 (0.45) | MAPK14AURKATTKAURKBINCENP | |
| SCHEMBL22612785 | 0.79 | SIK2 (0.45) | MAPK14AURKATTKAURKBINCENP | |
| SCHEMBL10323683 | 0.76 | MAPK8 (0.46) | MAPK14MAPK8MAPK10MAPK9GSK3B | |
| SCHEMBL31532117 | 0.75 | CDK4 (0.40) | MAPK14MAPK8MAPK10MAPK9ALDH1A1 | |
| SCHEMBL31532076 | 0.75 | CDK4 (0.42) | ALDH1A1IGF1RCDK4CCND1CCND2 | |
| SCHEMBL255621 | 0.74 | MEN1 (0.46) | ALDH1A1IGF1RMAPTCDK4GSK3B | |
| SCHEMBL15280148 | 0.73 | CDC7 (0.38) | ALDH1A1AURKAAURKBHDAC1HDAC6 | |
| SCHEMBL29861753 | 0.72 | PDK2 (0.39) | AURKAAURKBGSK3BCDK7 | |
| SCHEMBL23341176 | 0.71 | BRD4 (0.46) | MAPK14CDK4CCND1CDK2 | |
| SCHEMBL19868156 | 0.71 | CCNE1 (0.53) | MAPK8CDK4CCND1CCND3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025043349-A1 | PYRIMIDOPYRIDONE AND PTERIDONE DERIVATIVES AS INHIBITORS OF THE GCN2 KINASE, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2025-03-06 | — | — | WO | disclosed |