Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCND2 | P30279 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22612785 | 0.83 | SIK2 (0.45) | FGFR1AURKAAURKBDYRK1BIDH1 | |
| SCHEMBL31532055 | 0.83 | SIK2 (0.45) | FGFR1AURKAAURKBDYRK1BIDH1 | |
| SCHEMBL31532076 | 0.79 | CDK4 (0.42) | CDK4CCND1CCND2CCND3IGF1R | |
| SCHEMBL29861753 | 0.76 | PDK2 (0.39) | FGFR1KDRAURKADAPK3PRKD3 | |
| SCHEMBL255621 | 0.75 | MEN1 (0.46) | CDK4CCND1CCND2CCND3IGF1R | |
| SCHEMBL31532080 | 0.75 | MAPK14 (0.47) | CDK4CCND1CCND2CCND3IGF1R | |
| SCHEMBL15280148 | 0.74 | CDC7 (0.38) | FGFR1KDRAURKADAPK3PRKD3 | |
| SCHEMBL17910166 | 0.74 | MAPK8 (0.54) | CDK4CCND1CCND2CCND3IGF1R | |
| SCHEMBL29538008 | 0.73 | MEN1 (0.38) | ALDH1A1 | |
| SCHEMBL661610 | 0.73 | MEN1 (0.38) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025043349-A1 | PYRIMIDOPYRIDONE AND PTERIDONE DERIVATIVES AS INHIBITORS OF THE GCN2 KINASE, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2025-03-06 | — | — | WO | disclosed |