Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 13/20 | 0.41 |
| ▸ | LTA4H | P09960 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3153480 | 1.00 | SIGMAR1 (0.42) | SIGMAR1TMEM97LTA4HOPRM1ACKR3 | |
| SCHEMBL2123546 | 0.95 | ALDH1A1 (0.38) | SIGMAR1TMEM97LTA4H | |
| SCHEMBL2123549 | 0.95 | ALDH1A1 (0.38) | SIGMAR1TMEM97LTA4H | |
| SCHEMBL479558 | 0.93 | SIGMAR1 (0.42) | SIGMAR1TMEM97LTA4HOPRM1ACKR3 | |
| SCHEMBL479556 | 0.93 | SIGMAR1 (0.42) | SIGMAR1TMEM97LTA4HOPRM1ACKR3 | |
| SCHEMBL479554 | 0.93 | SIGMAR1 (0.42) | SIGMAR1TMEM97LTA4HOPRM1ACKR3 | |
| SCHEMBL2566188 | 0.90 | LTA4H (0.43) | SIGMAR1TMEM97LTA4H | |
| SCHEMBL2566183 | 0.90 | LTA4H (0.43) | SIGMAR1TMEM97LTA4H | |
| SCHEMBL3148338 | 0.90 | KDM4E (0.41) | SIGMAR1TMEM97LTA4H | |
| SCHEMBL3148349 | 0.90 | KDM4E (0.41) | SIGMAR1TMEM97LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2157081-A1 | Indolinones substituted in six locations, their manufacture and their application as medicine | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2010-02-24 | — | — | EP | disclosed |
| US-6762180-B1 | Substituted indolines which inhibit receptor tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-07-13 | — | — | US | disclosed |
| EP-1224170-A1 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | Boehringer Ingelheim Pharma KG (DE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027081-A1 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-04-19 | — | — | WO | disclosed |