Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL159595 | 0.80 | ALDH1A1 (0.39) | KDM4ESMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL2350414 | 0.80 | CA12 (0.35) | MAPTKDM4ECA9MAPK1S1PR4 | |
| SCHEMBL15389450 | 0.78 | MAPT (0.33) | MAPTKDM4ECA9MAPK1S1PR4 | |
| SCHEMBL8012068 | 0.78 | KDM4E (0.31) | KDM4ESMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL1225214 | 0.78 | NFE2L2 (0.36) | MAPTKDM4ECA9SMN1; SMN2MAPK1 | |
| SCHEMBL4697712 | 0.77 | PDE4A (0.41) | — | |
| SCHEMBL1299017 | 0.77 | MGAM (0.37) | MAPTKDM4ECA9SMN1; SMN2MAPK1 | |
| SCHEMBL16974713 | 0.77 | ALDH1A1 (0.33) | KDM4ESMN1; SMN2MAPK1TDP1CYP3A4 | |
| SCHEMBL1637723 | 0.77 | KDM4E (0.32) | MAPTKDM4ECA9SMN1; SMN2MAPK1 | |
| SCHEMBL5209906 | 0.77 | TP53 (0.43) | MAPTKDM4EMAPK1MCL1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049490-A1 | N-(BENZOYL)-O- [2- (PYRIDIN- 2 -YLAMINO) ETHYL]-L-TYROSINE DERIVATIVES AND RELATED COMPOUNDS AS A5B1 ANTAGONISTS FOR THE TREATMENT OF SOLID TUMORS | Astra Zeneca AB (SE) | 2009-04-22 | — | — | EP | claimed |
| US-20080045521-A1 | PHENYLALANINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | US | claimed |
| US-7326705-B2 | Heterocyclic sodium/proton exchange inhibitors and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-02-05 | — | — | US | claimed |
| WO-2007141473-A1 | N-(BENZOYL)-O- [2- (PYRIDIN- 2 -YLAMINO) ETHYL] -L-TYROSINE DERIVATIVES AND RELATED COMPOUNDS AS A5B1 ANTAGONISTS FOR THE TREATMENT OF SOLID TUMORS | ASTRAZENECA AB (SE) | 2007-12-13 | — | — | WO | claimed |
| US-20050137216-A1 | Heterocyclic sodium/proton exchange inhibitors and method | AHMAD SALEEM (US) | 2005-06-23 | — | — | US | claimed |
| US-6884815-B1 | High affinity small molecule C5a receptor modulators | NEUROGEN CORPORATION (US) | 2005-04-26 | — | — | US | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| EP-1041980-B1 | ACYL GUANIDINE SODIUM/PROTON EXCHANGE INHIBITORS AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2005-02-23 | — | — | EP | claimed |
| US-6534503-B1 | Treating sexual dysfunction, such as erectile dysfunction or sexual arousal disorder, with a compound having the generic formula X1-X2-(D)Phe-Arg-(D)Trp-X3. A particularly useful compound is HP-228, which has the formula | LION BIOSCIENCE AG (DE) | 2003-03-18 | — | — | US | claimed |
| EP-1224183-A2 | HETEROCYCLIC SODIUM/PROTON EXCHANGE INHIBITORS AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-07-24 | — | — | EP | claimed |
| US-4299896-A | Electrophotographic sensitive materials containing a disazo pigment | RICOH CO., LTD. (JP) | 1981-11-10 | — | — | US | claimed |
| US-4293628-A | Electrophotographic elements containing disazo compounds | RICOH CO., LTD. (JP) | 1981-10-06 | — | — | US | claimed |
| US-4279981-A | Electrophotographic elements containing trisazo compounds | RICOH COMPANY, LTD. (JP) | 1981-07-21 | — | — | US | claimed |
| US-4272598-A | STYRYL DYES | RICOH CO., LTD. (JP) | 1981-06-09 | — | — | US | claimed |
| US-4260672-A | Electrophotographic sensitive element having a photoconductive disazo pigment | RICOH COMPANY, LTD. (JP) | 1981-04-07 | — | — | US | claimed |
| US-4251614-A | CARBAZOLE DERIVATIVES | RICOH COMPANY, LTD. (JP) | 1981-02-17 | — | — | US | claimed |
| US-4251613-A | LAMINATE OF CONDUCTIVE SUPPORT AND PHOTOSENSITIVE LAYER | RICOH COMPANY, LTD. (JP) | 1981-02-17 | — | — | US | claimed |
| US-4250319-A | RIPENER FOR SUGARCANE | W. R. GRACE & CO. (US) | 1981-02-10 | — | — | US | claimed |
| EP-0012611-A2 | Electrophotographic element | Ricoh Company, Ltd (JP) | 1980-06-25 | — | — | EP | claimed |
| US-4010162-A | Substituted phenanthroline pigments | ALLIED CHEMICAL CORPORATION (US) | 1977-03-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045521-A1 | PHENYLALANINE DERIVATIVES | ITGB5, ITGB1, ITGA2B | MAPT 2378/4885KDM4E 2385/4885CA9 4623/4885 |
| US-20050137216-A1 | Heterocyclic sodium/proton exchange inhibitors and method | NHERF1, SLC9A3, SLC9A1 | MAPT 4881/4885KDM4E 4561/4885CA9 1752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.