Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 3/20 | 0.39 |
| ▸ | ANPEP | P15144 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18527603 | 0.94 | GABRA1 (0.37) | GABRA1GABRB2DPP4ANPEPTSHR | |
| Hydrochloric Acid SCHEMBL1609146 | 0.86 | ALDH1A1 (0.36) | DPP4ANPEPTSHRNR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL23326872 | 0.83 | ANPEP (0.36) | GABRA1GABRB2DPP4ANPEPTSHR | |
| Hydrochloric Acid SCHEMBL739370 | 0.80 | DPP4 (0.33) | GABRA1GABRB2DPP4ANPEPTSHR | |
| Hydrochloric Acid SCHEMBL1727633 | 0.79 | DPP4 (0.32) | GABRA1GABRB2DPP4ANPEPTSHR | |
| SCHEMBL819459 | 0.79 | DPP4 (0.33) | GABRA1GABRB2DPP4ANPEPTSHR | |
| Hydrochloric Acid SCHEMBL3156599 | 0.78 | IDH1 (0.33) | HPGDALDH1A1KDM4EMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL23326869 | 0.78 | GABRA1 (0.36) | GABRA1GABRB2DPP4ANPEPTSHR | |
| SCHEMBL2149891 | 0.77 | DPP4 (0.33) | GABRA1GABRB2DPP4ANPEPTSHR | |
| SCHEMBL12503773 | 0.77 | DPP4 (0.33) | GABRA1GABRB2DPP4ANPEPTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1582534-B1 | Olefin polymerization catalyst and polymerization process | ROHM & HAAS (US) | 2010-02-10 | — | — | EP | disclosed |
| US-7098278-B2 | Olefin polymerization catalyst and polymerization process | ROHM AND HAAS COMPANY (US) | 2006-08-29 | — | — | US | disclosed |
| US-20060128911-A1 | Olefin polymerization catalyst and polymerization process | GOODALL BRIAN L | 2006-06-15 | — | — | US | disclosed |
| US-7037987-B2 | Olefin polymerization catalyst and polymerization process | ROHN AND HAAS COMPANY (US) | 2006-05-02 | — | — | US | disclosed |
| EP-1582534-A1 | Olefin polymerization catalyst and polymerization process | ROHM AND HAAS COMPANY (US) | 2005-10-05 | — | — | EP | disclosed |
| US-20050215738-A1 | Olefin polymerization catalyst and polymerization process | ROHM AND HAAS COMPANY | 2005-09-29 | — | — | US | disclosed |