Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | USP2 | O75604 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3165286 | 0.93 | USP2 (0.57) | MAPTUSP2TSHRSMN1; SMN2LMNA | |
| SCHEMBL3162425 | 0.92 | EGFR (0.53) | MAPTUSP2TSHRSMN1; SMN2LMNA | |
| SCHEMBL3164831 | 0.90 | MAPT (0.50) | MAPTUSP2TSHRSMN1; SMN2LMNA | |
| SCHEMBL3156070 | 0.89 | TSHR (0.54) | MAPTUSP2TSHRSMN1; SMN2LMNA | |
| SCHEMBL3175543 | 0.88 | EGFR (0.50) | MAPTUSP2TSHRSMN1; SMN2LMNA | |
| SCHEMBL3169692 | 0.88 | ADORA3 (0.47) | MAPTUSP2TSHRSMN1; SMN2LMNA | |
| SCHEMBL3258722 | 0.87 | EGFR (0.46) | MAPTUSP2TSHRSMN1; SMN2LMNA | |
| SCHEMBL3170421 | 0.86 | SMN1; SMN2 (0.55) | USP2TSHRSMN1; SMN2HTTMEN1 | |
| SCHEMBL3166249 | 0.86 | GAA (0.54) | MAPTUSP2TSHRSMN1; SMN2MEN1 | |
| SCHEMBL3175833 | 0.86 | DRD4 (0.51) | MAPTUSP2TSHRSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |