Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3175833 | 0.92 | DRD4 (0.51) | KMT2AUSP2TSHRLMNASMN1; SMN2 | |
| SCHEMBL3165286 | 0.89 | USP2 (0.57) | ADORA3KMT2AUSP2TSHRLMNA | |
| SCHEMBL3156668 | 0.88 | MAPT (0.59) | KMT2AUSP2TSHRLMNASMN1; SMN2 | |
| SCHEMBL3177170 | 0.88 | NTSR1 (0.46) | ADORA3KMT2ANTSR1TSHRSMN1; SMN2 | |
| SCHEMBL3162796 | 0.85 | ADORA3 (0.53) | ADORA3KMT2AUSP2TSHRSMN1; SMN2 | |
| SCHEMBL3175773 | 0.84 | GAA (0.55) | KMT2ALMNASMN1; SMN2MAPTHTT | |
| SCHEMBL3156070 | 0.84 | TSHR (0.54) | ADORA3KMT2AUSP2TSHRLMNA | |
| SCHEMBL3162425 | 0.84 | EGFR (0.53) | KMT2AUSP2TSHRLMNASMN1; SMN2 | |
| SCHEMBL3163835 | 0.84 | MEN1 (0.46) | ADORA3KMT2AUSP2LMNAHTT | |
| SCHEMBL3162900 | 0.84 | MAPT (0.44) | KMT2ATSHRLMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |