Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 5/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.58 |
| ▸ | AGXT | P21549 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2780134 | 0.92 | CYP2A6 (0.50) | CYP2A6CYP1A2AGXTTDP1KDM4E | |
| SCHEMBL2779866 | 0.84 | ALDH1A1 (0.54) | CYP2A6CYP1A2AGXTTDP1GAA | |
| SCHEMBL2781194 | 0.81 | ALDH1A1 (0.56) | CYP2A6CYP1A2AGXTTDP1MAPT | |
| SCHEMBL3500443 | 0.80 | CYP2A6 (0.67) | CYP2A6CYP1A2AGXTTDP1KDM4E | |
| SCHEMBL395026 | 0.78 | CYP1A2 (0.64) | CYP2A6CYP1A2AGXTTDP1KDM4E | |
| SCHEMBL29366638 | 0.78 | CYP1A2 (0.64) | CYP2A6CYP1A2AGXTTDP1KDM4E | |
| SCHEMBL29378143 | 0.76 | CYP1A2 (0.61) | CYP2A6CYP1A2AGXTTDP1KDM4E | |
| Hydrochloric Acid SCHEMBL9443225 | 0.76 | CYP1A2 (0.61) | CYP2A6CYP1A2AGXTTDP1KDM4E | |
| Ethylene SCHEMBL9815947 | 0.75 | CYP1A2 (0.91) | CYP2A6CYP1A2AGXTTDP1KDM4E | |
| SCHEMBL27269655 | 0.75 | CYP2A6 (0.52) | CYP2A6CYP1A2TDP1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 522 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802303-B1 | COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY | WHITEHEAD BIOMEDICAL INST (US) | 2011-11-02 | — | — | EP | claimed |
| US-20080261953-A1 | Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2008-10-23 | — | — | US | claimed |
| EP-1976839-A2 | COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING | Foldrx Pharmaceuticals, Inc. (US) | 2008-10-08 | — | — | EP | claimed |
| WO-2007089548-A2 | COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2007-08-09 | — | — | WO | claimed |
| EP-1802303-A2 | COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2007-07-04 | — | — | EP | claimed |
| WO-2006034003-A2 | COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2006-03-30 | — | — | WO | claimed |
| EP-1074544-B1 | Process for production of 3-(3-pyridyl)-1-propanol derivatives | KANEKA CORP (JP) | 2003-08-27 | — | — | EP | claimed |
| EP-1210598-A4 | 4-UNSUBSTITUTED DIHYDROISOQUINOLINONE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2002-10-30 | — | — | EP | claimed |
| US-6452009-B1 | A LARGE NUMBER OF RELATED ANALOGS ARE THEN SYNTHESIZED IN ORDER TO DEVELOP A STRUCTURE-ACTIVITY RELATIONSHIP | LION BIOSCIENCE AG (DE) | 2002-09-17 | — | — | US | claimed |
| EP-1210598-A1 | 4-UNSUBSTITUTED DIHYDROISOQUINOLINONE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION bioscience AG (DE) | 2002-06-05 | — | — | EP | claimed |
| US-6255120-B1 | HYDROXYAMIDES ATTACHED TO SOLID SUPPORT | PHARMACOPEIA, INC. | 2001-07-03 | — | — | US | claimed |
| WO-2001014879-A1 | 4-UNSUBSTITUTED DIHYDROISOQUINOLINONE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-03-01 | — | — | WO | claimed |
| US-5976894-A | FOR SCREENING BIOASSAYS TO DISCOVER BIOLOGICALLY ACTIVE MEMBERS | PHARMACOPEIA, INC. (US) | 1999-11-02 | — | — | US | claimed |
| EP-0667850-B1 | TARTRONIC ACIDS, THEIR ACETALIC ETHERS AND O-ESTERS | DOMPE FARMACEUTICI SPA (IT) | 1997-05-28 | — | — | EP | claimed |
| US-5530128-A | ENZYME INHIBITOR AS ANTITUMOR AGENT | CELLTECH THERAPEUTICS LIMITED (GB) | 1996-06-25 | — | — | US | claimed |
| EP-0667850-A1 | TARTRONIC ACIDS, THEIR ACETALIC ETHERS AND O-ESTERS. | DOMPE FARMACEUTICI SPA (IT) | 1995-08-23 | — | — | EP | claimed |
| WO-1994010127-A1 | TARTRONIC ACIDS, THEIR ACETALIC ETHERS AND O-ESTERS | DOMPE' FARMACEUTICI S.P.A. (IT) | 1994-05-11 | — | — | WO | claimed |
| US-5120849-A | Reacting cyclic imidoether with aminoalcohol | BASF AKTIENGESELLSCHAFT (DE) | 1992-06-09 | — | — | US | claimed |
| EP-0127726-B1 | HYDROXAMIC ACIDS, THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | VEB Fahlberg-List Magdeburg (DD) | 1987-08-26 | — | — | EP | claimed |
| US-4112219-A | Acyl derivatives of antibiotic BM123γ | AMERICAN CYANAMID COMPANY (US) | 1978-09-05 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261953-A1 | Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity | SNCA, PARK7, HTT | CYP2A6 3247/4885CYP1A2 2530/4885AGXT 2163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.