Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.56 |
| ▸ | CRHBP | P24387 | 2/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.54 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3161766 | 0.90 | CYP1A2 (0.75) | CYP2C19CYP1A2CYP2D6CYP2C9KCNH2 | |
| SCHEMBL15392240 | 0.88 | LOXL2 (0.59) | CYP2C19CYP1A2CYP2D6CYP2C9KCNH2 | |
| SCHEMBL22340481 | 0.85 | CYP1A2 (0.50) | CYP2C19CYP1A2CYP2D6CYP2C9KCNH2 | |
| SCHEMBL7231705 | 0.85 | PYCR1 (0.55) | CYP2C19CYP1A2CYP2D6CYP2C9KCNH2 | |
| SCHEMBL1206139 | 0.85 | HRH3 (0.58) | CYP2C19CYP1A2CYP2D6CYP2C9KCNH2 | |
| SCHEMBL1852954 | 0.84 | CYP1A2 (0.56) | CYP2C19CYP1A2CYP2D6CYP2C9KCNH2 | |
| SCHEMBL3154646 | 0.83 | PYCR1 (0.66) | CYP2C19CYP1A2CYP2D6CYP2C9KCNH2 | |
| SCHEMBL17539702 | 0.83 | CYP1A2 (0.62) | CYP2C19CYP1A2CYP2D6CYP2C9KCNH2 | |
| SCHEMBL3157762 | 0.81 | KCNH2 (0.71) | KCNH2HRH3LOXL2TSHRATM | |
| SCHEMBL9628232 | 0.81 | KCNH2 (0.76) | KCNH2HRH3LOXL2TSHRATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108715589-B | Coumarin derivative used as caspase-3 activator and application thereof | 华侨大学 | 2021-04-20 | — | — | CN | disclosed |
| CN-109265453-A | It is a kind of as the semicarbazones analog derivative of caspase-3 activator and its application | 华侨大学 | 2019-01-25 | — | — | CN | disclosed |
| EP-1224170-B9 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | BOEHRINGER INGELHEIM PHARMA (DE) | 2017-11-22 | — | — | EP | disclosed |
| CN-104230845-B | Semicarbazone derivatives and application thereof | 沈阳药科大学 | 2017-01-25 | — | — | CN | disclosed |
| CN-104230845-A | Semicarbazone derivatives and application thereof | UNIV SHENYANG PHARMACEUTICAL | 2014-12-24 | — | — | CN | disclosed |
| US-20120149866-A1 | Solvent resistant polymers | MOHANTY DILLIP K (US) | 2012-06-14 | — | — | US | disclosed |
| US-20120149866-A1 | Solvent resistant polymers | MOHANTY DILLIP K (US) | 2012-06-14 | — | — | US | disclosed |
| US-8101708-B2 | Solvent resistant polymers | MOHANTY DILLIP K (US) | 2012-01-24 | — | — | US | disclosed |
| US-8101708-B2 | Solvent resistant polymers | MOHANTY DILLIP K (US) | 2012-01-24 | — | — | US | disclosed |
| US-20110172385-A1 | Solvent resistant polymers | MOHANTY DILLIP K | 2011-07-14 | — | — | US | disclosed |
| US-20070299070-A1 | 2-Arylcarboxamide-Nitrogenous Heterocycle Compound | MSD K.K. (JP) | 2007-12-27 | — | — | US | disclosed |
| CN-101065356-A | 2-arylcarboxamide-nitrogen-containing heterocyclic compounds | BANYU PHARMA CO LTD (JP) | 2007-10-31 | — | — | CN | disclosed |
| EP-1798221-A1 | 2-ARYLCARBOXAMIDE-NITROGENEOUS HETEROCYCLE COMPOUND | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-06-20 | — | — | EP | disclosed |
| US-20070032478-A1 | Kinase Inhibitors | ALLERGAN, INC. | 2007-02-08 | — | — | US | disclosed |
| WO-2007008895-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2007-01-18 | — | — | WO | disclosed |
| US-6762180-B1 | Substituted indolines which inhibit receptor tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-07-13 | — | — | US | disclosed |
| CN-1391557-A | 6-substituted indolinones, their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-01-15 | — | — | CN | disclosed |
| EP-1224170-A1 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | Boehringer Ingelheim Pharma KG (DE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027081-A1 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-04-19 | — | — | WO | disclosed |
| US-4339461-A | FUNGICIDES | CHEVRON RESEARCH COMPANY (US) | 1982-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299070-A1 | 2-Arylcarboxamide-Nitrogenous Heterocycle Compound | MCHR2, MCHR1, NPY2R | CYP2C19 389/4885CYP1A2 180/4885CYP2D6 686/4885 |
| US-20070032478-A1 | Kinase Inhibitors | ABL1, LCK, ERBB2 | CYP2C19 4389/4885CYP1A2 4043/4885CYP2D6 3664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.