SCHEMBL31571990

SCHEMBL31571990

O=C(O)Cc1ccc(CSc2nc3ccccc3c3cc(CNC(=O)c4ccccc4OC(F)(F)F)nn23)cc1

nearest known ligand 0.42

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
RORC P51449 8/20 0.42
SMN1; SMN2 Q16637 1/20 0.41
MAPT P10636 1/20 0.38
THRB P10828 2/20 0.37
EGFR P00533 1/20 0.37
BTK Q06187 1/20 0.37
LMNA P02545 3/20 0.36
PTGER4 P35408 1/20 0.36
PTGDR2 Q9Y5Y4 1/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
USP2 O75604 1/20 0.36
RAB9A P51151 1/20 0.36
TP53 P04637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31675879 0.89 POLB (0.38) EGFRBTKLMNAPTGER4L3MBTL1
SCHEMBL26601311 0.89 POLB (0.38) EGFRBTKLMNAPTGER4L3MBTL1
SCHEMBL31571994 0.87 KMT2A (0.41) RORCSMN1; SMN2MAPTEGFRBTK
SCHEMBL26630686 0.86 EGFR (0.37) SMN1; SMN2MAPTEGFRBTKLMNA
SCHEMBL31461702 0.85 ALDH1A1 (0.41) EGFRBTKLMNAPTGER4L3MBTL1
SCHEMBL26629775 0.85 ALDH1A1 (0.41) EGFRBTKLMNAPTGER4L3MBTL1
SCHEMBL31461697 0.85 ALDH1A1 (0.41) EGFRBTKLMNAPTGER4L3MBTL1
Trifluoroacetic Acid SCHEMBL26601324 0.84 EGFR (0.38) SMN1; SMN2MAPTEGFRBTKPTGER4
Trifluoroacetic Acid SCHEMBL30623528 0.84 EGFR (0.38) SMN1; SMN2MAPTEGFRBTKPTGER4
SCHEMBL31571999 0.83 ADRA2A (0.39) SMN1; SMN2MAPTTHRBEGFRBTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025090847-A1 ESTROGEN RECEPTOR DEGRADERS AND THEIR USE IN THE TREATMENT OF CANCER BPGBIO, INC. (US) 2025-05-01 WO disclosed