Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206269 | 0.80 | — | — | |
| SCHEMBL29173644 | 0.80 | — | — | |
| SCHEMBL31577281 | 0.76 | RPS6KA5 (0.41) | JAK2JAK3TP53MAPTSMN1; SMN2 | |
| SCHEMBL31577393 | 0.75 | TP53 (0.31) | TP53 | |
| SCHEMBL31577323 | 0.75 | NAMPT (0.30) | NAMPT | |
| SCHEMBL24944445 | 0.73 | SYK (0.31) | JAK3 | |
| SCHEMBL30205684 | 0.73 | SYK (0.31) | JAK3 | |
| SCHEMBL31577344 | 0.71 | BRD4 (0.30) | — | |
| SCHEMBL31577373 | 0.70 | JAK2 (0.43) | JAK2JAK3 | |
| SCHEMBL31577284 | 0.70 | LRRK2 (0.41) | JAK2JAK3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | disclosed |