Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 2/20 | 0.30 |
| ▸ | CDK2 | P24941 | 2/20 | 0.30 |
| ▸ | KDR | P35968 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206222 | 0.81 | GPR119 (0.32) | — | |
| SCHEMBL31577393 | 0.75 | TP53 (0.31) | — | |
| SCHEMBL31577373 | 0.74 | JAK2 (0.43) | — | |
| SCHEMBL31577281 | 0.73 | RPS6KA5 (0.41) | — | |
| SCHEMBL31577303 | 0.71 | JAK2 (0.32) | — | |
| SCHEMBL31577339 | 0.70 | BMI1 (0.37) | KDR | |
| SCHEMBL31219609 | 0.68 | ABL1 (0.37) | CDK1CDK2KDR | |
| SCHEMBL31577350 | 0.67 | AOC3 (0.37) | — | |
| SCHEMBL31577293 | 0.65 | RPS6KA5 (0.41) | — | |
| SCHEMBL30205929 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | disclosed |