Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | SHMT2 | P34897 | 5/20 | 0.44 |
| ▸ | SHMT1 | P34896 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31578642 | 0.87 | SHMT2 (0.55) | SHMT2SHMT1ALDH1A1GAAKDM4E | |
| SCHEMBL31578724 | 0.78 | SHMT2 (0.53) | SHMT2SHMT1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL31578879 | 0.78 | SHMT2 (0.48) | SHMT2SHMT1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL31578675 | 0.77 | NPC1 (0.42) | NPC1RAB9ACLK1SHMT2SHMT1 | |
| SCHEMBL31578832 | 0.76 | SHMT2 (0.54) | NPC1RAB9ASHMT2SHMT1TP53 | |
| SCHEMBL31578885 | 0.75 | SHMT2 (0.52) | NPC1RAB9ASHMT2SHMT1TP53 | |
| SCHEMBL20255697 | 0.72 | SHMT2 (0.66) | NPC1RAB9ASHMT2SHMT1SMN1; SMN2 | |
| SCHEMBL31057887 | 0.71 | SHMT2 (0.44) | SHMT2SHMT1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL20241556 | 0.70 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1GAAMAPT | |
| SCHEMBL31578923 | 0.70 | SHMT2 (0.55) | SHMT2SHMT1TP53SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250163075-A1 | HETEROBIFUNCTIONAL TARGETED PROTEIN DEGRADERS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2025-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250163075-A1 | HETEROBIFUNCTIONAL TARGETED PROTEIN DEGRADERS | KLHDC2, KLHL6, KLHL20 | NPC1 2661/4885RAB9A 3624/4885CLK1 1113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.