Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827518 | 0.75 | ALDH1A1 (0.57) | ALDH1A1NPC1MITFHTTSMN1; SMN2 | |
| SCHEMBL27524456 | 0.74 | TSHR (0.35) | KDM4EMAPK1ALDH1A1NPC1MITF | |
| SCHEMBL31584352 | 0.73 | FPR2 (0.41) | TNF | |
| SCHEMBL31487688 | 0.69 | HDAC8 (0.32) | KDM4EALDH1A1HDAC8 | |
| SCHEMBL22787170 | 0.68 | TNF (0.30) | KDM4ETNF | |
| SCHEMBL31487600 | 0.68 | HDAC8 (0.33) | KDM4EALDH1A1KAT2BHDAC8 | |
| SCHEMBL31584367 | 0.68 | TNF (0.37) | KDM4EALDH1A1TNF | |
| SCHEMBL25342529 | 0.67 | NLRP3 (0.47) | KDM4EMAPK1ALDH1A1NPC1MITF | |
| SCHEMBL12638925 | 0.67 | KMT2A (0.61) | MAPK1ALDH1A1HSD17B10HDAC8KMT2A | |
| SCHEMBL23971227 | 0.67 | FLT1 (0.35) | MAPK1ALDH1A1NPC1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025106863-A1 | LACTAM DERIVATIVES FOR INHIBITING NLRP3 AND USES THEREOF | VENTUS THERAPEUTICS U.S., INC. (US) | 2025-05-22 | — | — | WO | disclosed |