Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 2/20 | 0.32 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | SI | P14410 | 2/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20529673 | 0.75 | TDO2 (0.41) | GRM2KMOKDM4EALDH1A1SLC9A1 | |
| SCHEMBL30701769 | 0.75 | TDO2 (0.41) | GRM2KMOKDM4EALDH1A1SLC9A1 | |
| SCHEMBL24851152 | 0.73 | HTR2A (0.51) | KMOHTR2AHTR2C | |
| SCHEMBL17604612 | 0.72 | DGAT1 (0.31) | NPC1RAB9A | |
| SCHEMBL29342015 | 0.70 | GRM2 (0.44) | GRM2POLBAPAF1HTR2AHTR2C | |
| SCHEMBL31599748 | 0.70 | AURKA (0.30) | HTR2AHTR2C | |
| SCHEMBL7716431 | 0.68 | APAF1 (0.67) | GRM2POLBAPAF1LMNAALDH1A1 | |
| SCHEMBL30555641 | 0.67 | HCAR3 (0.43) | GAAKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL15742045 | 0.67 | HCAR3 (0.43) | GAAKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL29342227 | 0.67 | MAPT (0.44) | GRM2POLBAPAF1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025111251-A1 | COMPOUNDS THAT INHIBIT POLO-LIKE KINASE 4 | EXELIXIS, INC. (US) | 2025-05-30 | — | — | WO | disclosed |