Sugi Predict

Sugi Predict / Compounds / SCHEMBL316028

SCHEMBL316028

SCHEMBL316028

O[C@H](CCl)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.58
▸ KDM4E B2RXH2 2/20 0.56
▸ L3MBTL1 Q9Y468 1/20 0.56
▸ AOC3 Q16853 5/20 0.52
▸ RIPK1 Q13546 1/20 0.48
▸ BCAT2 O15382 1/20 0.45
▸ NPC1 O15118 1/20 0.44
▸ RAB9A P51151 1/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ TSHR P16473 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL219295 1.00 LMNA (0.58) LMNAKDM4EL3MBTL1AOC3RIPK1
SCHEMBL932391 1.00 LMNA (0.58) LMNAKDM4EL3MBTL1AOC3RIPK1
SCHEMBL6487259 0.86 LMNA (0.47) LMNAKDM4EL3MBTL1AOC3
SCHEMBL1142222 0.80 RIPK1 (0.55) LMNAKDM4EL3MBTL1AOC3RIPK1
SCHEMBL1200943 0.80 RIPK1 (0.55) LMNAKDM4EL3MBTL1AOC3RIPK1
SCHEMBL525669 0.80 RIPK1 (0.55) LMNAKDM4EL3MBTL1AOC3RIPK1
SCHEMBL29926486 0.80 RIPK1 (0.55) LMNAKDM4EL3MBTL1AOC3RIPK1
SCHEMBL10799093 0.79 TAAR1 (0.39) LMNAKDM4EL3MBTL1AOC3SMN1; SMN2
SCHEMBL30716448 0.78 RIPK1 (0.53) LMNAKDM4EL3MBTL1AOC3RIPK1
Phenylpropanol SCHEMBL28598207 0.78 LMNA (0.86) LMNAKDM4EL3MBTL1AOC3RIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 163 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101503714-A Method for asymmetric synthesis of (S)-2-chloro-1-phenylethanol derivative UNIV GUANGDONG TECHNOLOGY (CN) 2009-08-12 — — CN claimed
EP-0288994-B1 PROCESS FOR PRODUCING OPTICALLY ACTIVE COMPOUNDS Chisso Corporation (JP) 1992-07-22 — — EP claimed
US-4996158-A Optical resolution of racemic alcohols LION CORPORATION, 3-7, HONJO 1-CHOME, SUMIDA-KU, TOKYO, JAPAN 1991-02-26 — — US claimed
US-4962031-A SPECIFIC COMPOUNDS HAVING HYDROXYL GROUPS REACTED WITH ESTERS IN PRESENCE OF HYDROLASES CHISSO CORPORATION (JP) 1990-10-09 — — US claimed
EP-0288994-A2 Process for producing optically active compounds Chisso Corporation (JP) 1988-11-02 — — EP claimed
CN-117821525-A Enzymatic synthesis method of halohydrin medicine chiral building block 宁波酶赛生物工程有限公司 2024-04-05 — — CN disclosed
EP-4257593-A1 CHIRAL MULTIDENTATE LIGAND AND USE THEREOF IN ASYMMETRIC HYDROGENATION SHENZHEN CATALYS TECHNOLOGY CO., LTD. (CN) 2023-10-11 — — EP disclosed
US-20230212149-A1 TRIAZOLE CARBAMATE PYRIDYL SULFONAMIDES AS LPA RECEPTOR ANTAGONISTS AND USES THEREOF GILEAD SCIENCES, INC. 2023-07-06 — — US disclosed
US-20230212149-A1 TRIAZOLE CARBAMATE PYRIDYL SULFONAMIDES AS LPA RECEPTOR ANTAGONISTS AND USES THEREOF GILEAD SCIENCES, INC. 2023-07-06 — — US disclosed
WO-2023077643-A1 CHIRAL MULTIDENTATE LIGAND AND USE THEREOF IN ASYMMETRIC HYDROGENATION 凯特立斯（深圳）科技有限公司 2023-05-11 — — WO disclosed
US-20230124576-A1 CHIRAL MULTIDENTATE LIGAND, AND APPLICATION THEREOF IN ASYMMETRIC HYDROGENATION SHENZHEN CATALYS TECHNOLOGY CO., LTD (CN) 2023-04-20 — — US disclosed
US-11548871-B2 Triazole carbamate pyridyl sulfonamides as LPA receptor antagonists and uses thereof GILEAD SCIENCES, INC. (US) 2023-01-10 — — US disclosed
US-5495054-A REDUCING PROCHIRAL KETONES TO ENANTIOMERICALLY PURE ALCOHOLS WITH BORANE REDUCING AGENT SEPRACOR, INC. (US) 1996-02-27 — — US disclosed
WO-1995032937-A1 TETRAHYDROINDENO[1,2-d][1,3,2]OXAZABOROLES AND THEIR USE AS ENANTIOSELECTIVE CATALYSTS SEPRACOR, INC. (US) 1995-12-07 — — WO disclosed
EP-0198440-B1 PROCESS FOR PREPARING OPTICALLY ACTIVE 2-HALO-1-PHENYL ETHANOL KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1992-08-26 — — EP disclosed
EP-0288994-B1 PROCESS FOR PRODUCING OPTICALLY ACTIVE COMPOUNDS Chisso Corporation (JP) 1992-07-22 — — EP disclosed
US-4996158-A Optical resolution of racemic alcohols LION CORPORATION, 3-7, HONJO 1-CHOME, SUMIDA-KU, TOKYO, JAPAN 1991-02-26 — — US disclosed
US-4962031-A SPECIFIC COMPOUNDS HAVING HYDROXYL GROUPS REACTED WITH ESTERS IN PRESENCE OF HYDROLASES CHISSO CORPORATION (JP) 1990-10-09 — — US disclosed
US-4857468-A BIOSYNTHESIS KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1989-08-15 — — US disclosed
EP-0288994-A2 Process for producing optically active compounds Chisso Corporation (JP) 1988-11-02 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11548871-B2 Triazole carbamate pyridyl sulfonamides as LPA receptor antagonists and uses thereof LPAR3, LPAR1, LPAR2 LMNA 1879/4885KDM4E 2137/4885L3MBTL1 2693/4885
US-20230124576-A1 CHIRAL MULTIDENTATE LIGAND, AND APPLICATION THEREOF IN ASYMMETRIC HYDROGENATION H1-4, CHRM1, CHRM2 LMNA 1366/4885KDM4E 1081/4885L3MBTL1 164/4885
US-20230212149-A1 TRIAZOLE CARBAMATE PYRIDYL SULFONAMIDES AS LPA RECEPTOR ANTAGONISTS AND USES THEREOF LPAR3, LPAR1, LPAR2 LMNA 1879/4885KDM4E 2137/4885L3MBTL1 2693/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.