SCHEMBL31604471

SCHEMBL31604471

Cc1cc2ccc(Oc3cccc(F)c3)cn2c1C(=O)NC1(CO)CCNC1=O

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 1/20 0.35
HIF1A Q16665 1/20 0.35
HTR2C P28335 1/20 0.34
HTR2B P41595 1/20 0.34
GCK P35557 2/20 0.33
BTK Q06187 2/20 0.33
TTK P33981 2/20 0.33
MMP14 P50281 2/20 0.33
POLB P06746 1/20 0.33
KIT P10721 1/20 0.33
FLT3 P36888 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A3 Q01959 1/20 0.33
EGLN1 Q9GZT9 1/20 0.32
MMP13 P45452 2/20 0.32
S1PR2 O95136 1/20 0.32
KDM4E B2RXH2 1/20 0.32
ABL1 P00519 1/20 0.32
MMP1 P03956 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31604469 0.92 EZH2 (0.36) GCKBTKMMP14POLBEGLN1
SCHEMBL31604476 0.91 S1PR2 (0.33) SCN9AHIF1AS1PR2
SCHEMBL31604467 0.91 MTNR1B (0.36) HIF1ABTKEGLN1MMP13
SCHEMBL31604468 0.91 BTK (0.37) HTR2CBTKSLC6A3KDM4E
SCHEMBL31604479 0.88 MMP13 (0.33) BTKMMP13S1PR2KDM4E
SCHEMBL31604491 0.87 HPGDS (0.35) HIF1ABTKMMP13S1PR2MMP1
SCHEMBL31604484 0.87 HIF1A (0.34) HIF1AGCKBTKMMP14EGLN1
SCHEMBL31604495 0.85 EZH2 (0.35) GCKBTKMMP14EGLN1MMP13
SCHEMBL31604486 0.84 KMT2A (0.36) HIF1ABTKMMP13
SCHEMBL26830820 0.82 MGLL (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025111415-A1 TRPM3-MODULATING INDOLIZINE DERIVATIVES KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2025-05-30 WO claimed
WO-2025111415-A1 TRPM3-MODULATING INDOLIZINE DERIVATIVES KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2025-05-30 WO disclosed