SCHEMBL31604516

SCHEMBL31604516

Cc1ccccc1Oc1ccc2cc(C)c(C(=O)NC3(CO[Si](C)(C)C(C)(C)C)CCNC3=O)n2c1

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 1/20 0.33
EZH2 Q15910 1/20 0.32
S1PR2 O95136 1/20 0.31
EGLN2 Q96KS0 1/20 0.31
EGLN1 Q9GZT9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31604495 0.87 EZH2 (0.35) MAPK14EZH2S1PR2EGLN2EGLN1
SCHEMBL31604486 0.82 KMT2A (0.36) EZH2
SCHEMBL31604484 0.80 HIF1A (0.34) EGLN2EGLN1
SCHEMBL31604468 0.79 BTK (0.37)
SCHEMBL31604491 0.77 HPGDS (0.35) S1PR2
SCHEMBL31604476 0.76 S1PR2 (0.33) S1PR2
SCHEMBL31604479 0.76 MMP13 (0.33) MAPK14S1PR2
SCHEMBL31604467 0.76 MTNR1B (0.36) EGLN1
SCHEMBL31604469 0.75 EZH2 (0.36) EZH2S1PR2EGLN1
SCHEMBL31604471 0.74 SCN9A (0.35) S1PR2EGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025111415-A1 TRPM3-MODULATING INDOLIZINE DERIVATIVES KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2025-05-30 WO disclosed