Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GHSR | Q92847 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL315428 | 0.95 | GHSR (0.56) | KMT2AMEN1GHSRABCB11ALDH1A1 | |
| SCHEMBL316302 | 0.94 | GHSR (0.56) | KMT2AMEN1GHSRABCB11ALDH1A1 | |
| SCHEMBL315461 | 0.90 | KMT2A (0.65) | KMT2AMEN1SMN1; SMN2GHSRL3MBTL1 | |
| SCHEMBL316051 | 0.89 | KMT2A (0.67) | KMT2AMEN1SMN1; SMN2GHSRABCB11 | |
| SCHEMBL315998 | 0.85 | KMT2A (0.57) | KMT2AMEN1SMN1; SMN2GHSRL3MBTL1 | |
| SCHEMBL316299 | 0.85 | KMT2A (0.57) | KMT2AMEN1SMN1; SMN2GHSRNPC1 | |
| SCHEMBL316155 | 0.81 | KMT2A (0.56) | KMT2AMEN1SMN1; SMN2GHSRNPC1 | |
| SCHEMBL316159 | 0.80 | KMT2A (0.58) | KMT2AMEN1GHSRABCB11ALDH1A1 | |
| SCHEMBL314979 | 0.80 | GHSR (0.62) | KMT2AMEN1GHSRALDH1A1MAPT | |
| SCHEMBL315817 | 0.80 | GHSR (0.56) | KMT2AMEN1SMN1; SMN2GHSRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093272-B2 | Heteroaryl substituted cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2012-01-10 | — | — | US | claimed |
| US-8093272-B2 | Heteroaryl substituted cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2012-01-10 | — | — | US | disclosed |