Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.49 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4275826 | 0.92 | HDAC1 (0.56) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL14566050 | 0.87 | MAPT (0.56) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL13612294 | 0.85 | L3MBTL1 (0.57) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL809948 | 0.85 | NR5A1 (0.59) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL14163893 | 0.85 | L3MBTL1 (0.57) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL810018 | 0.85 | PPARD (0.53) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL21260769 | 0.85 | L3MBTL1 (0.57) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL3170654 | 0.84 | LTA4H (0.52) | GAAMAPTHTTLTA4H | |
| SCHEMBL14883463 | 0.84 | HDAC1 (0.51) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL13933074 | 0.84 | HDAC1 (0.50) | HDAC1HDAC8HDAC6HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642373-B2 | Forming for example [18F]-dopamine or [18F]-uracil via reaction of iodonium salt precursor, where use of free radical scavenger improves yield of aryl fluoride | GE HEALTHCARE LIMITED (GB) | 2010-01-05 | — | — | US | disclosed |
| US-7642373-B2 | Forming for example [18F]-dopamine or [18F]-uracil via reaction of iodonium salt precursor, where use of free radical scavenger improves yield of aryl fluoride | GE HEALTHCARE LIMITED (GB) | 2010-01-05 | — | — | US | disclosed |
| US-7642373-B2 | Forming for example [18F]-dopamine or [18F]-uracil via reaction of iodonium salt precursor, where use of free radical scavenger improves yield of aryl fluoride | GE HEALTHCARE LIMITED (GB) | 2010-01-05 | — | — | US | disclosed |
| EP-1697279-B1 | RADICAL TRAP IN FLUORIDATION OF IODINIUM SALT | GE HEALTHCARE LTD (GB) | 2008-09-24 | — | — | EP | disclosed |
| EP-1697279-B1 | RADICAL TRAP IN FLUORIDATION OF IODINIUM SALT | GE HEALTHCARE LTD (GB) | 2008-09-24 | — | — | EP | disclosed |
| US-20060292060-A1 | Forming for example [18F]-dopamine or [18F]-uracil via reaction of iodonium salt precursor, where use of free radical scavenger improves yield of aryl fluoride | GE HEALTHCARE LIMITED (GB) | 2006-12-28 | — | — | US | disclosed |
| EP-1697279-A1 | RADICAL TRAP IN FLUORIDATION OF IODINIUM SALT | GE Healthcare Limited (GB) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061415-A1 | RADICAL TRAP IN FLUORIDATION OF IODONIUM SALT | GE HEALTHCARE LIMITED (GB) | 2005-07-07 | — | — | WO | disclosed |