SCHEMBL31635975

SCHEMBL31635975

O=C(CBr)c1c[nH]c2ncc(Br)cc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 4/20 0.46
AURKA O14965 2/20 0.46
JAK2 O60674 2/20 0.46
PRKD3 O94806 2/20 0.46
MAP4K4 O95819 2/20 0.46
FGFR1 P11362 2/20 0.46
FLT1 P17948 2/20 0.46
KDR P35968 2/20 0.46
CLK2 P49760 2/20 0.46
CDK5 Q00535 2/20 0.46
MAP4K2 Q12851 2/20 0.46
DYRK1A Q13627 2/20 0.46
TAOK1 Q7L7X3 2/20 0.46
AURKB Q96GD4 2/20 0.46
CLK4 Q9HAZ1 2/20 0.46
PLK4 O00444 1/20 0.46
ROCK2 O75116 1/20 0.46
PRKCG P05129 1/20 0.46
INSR P06213 1/20 0.46
CDK1 P06493 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1516742 1.00 CDK2 (0.46) CDK2AURKAJAK2PRKD3MAP4K4
SCHEMBL7520159 0.88 AURKA (0.46) CDK2AURKAJAK2PRKD3MAP4K4
SCHEMBL8478533 0.87 PLK4 (0.44) CDK2AURKAJAK2PRKD3MAP4K4
SCHEMBL9888004 0.87 CDK2 (0.44) CDK2AURKAJAK2PRKD3MAP4K4
SCHEMBL13888091 0.85 AXL (0.40) CDK2DYRK1AAXLMTNR1AMTNR1B
SCHEMBL28046056 0.84 BRAF (0.53) CDK2AURKAJAK2PRKD3MAP4K4
SCHEMBL4828101 0.84 AURKA (0.54) CDK2AURKAJAK2PRKD3MAP4K4
SCHEMBL8469861 0.84 AXL (0.39) CDK2BRAFAXLMTNR1AMTNR1B
SCHEMBL4481118 0.84 AXL (0.39) JAK2DYRK1AFLT3BRAFAXL
SCHEMBL31635976 0.84 AXL (0.39) JAK2DYRK1AFLT3BRAFAXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250361233-A1 Compounds For Activating Serotonin Receptor Psylo Pty Ltd (AU) 2025-11-27 US disclosed
US-12415804-B2 Compounds for activating a serotonin receptor Psylo Pty Ltd (AU) 2025-09-16 US disclosed
US-20250206739-A1 Compounds Psylo Pty Ltd (AU) 2025-06-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250206739-A1 Compounds NLN, SLC18A2, PYGB CDK2 904/4885AURKA 4020/4885JAK2 2202/4885
US-12415804-B2 Compounds for activating a serotonin receptor HTR2C, HTR6, HTR2A CDK2 1527/4885AURKA 3782/4885JAK2 2353/4885
US-20250361233-A1 Compounds For Activating Serotonin Receptor HTR2C, HTR2A, HTR6 CDK2 1458/4885AURKA 3836/4885JAK2 2157/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.