SCHEMBL31635976

SCHEMBL31635976

O=C(CBr)c1c[nH]c2ncc(F)cc12

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
AXL P30530 5/20 0.39
GSK3A P49840 2/20 0.39
GSK3B P49841 2/20 0.39
BRAF P15056 3/20 0.37
CYP3A4 P08684 1/20 0.37
HTR1A P08908 1/20 0.37
CYP2D6 P10635 1/20 0.37
DRD2 P14416 1/20 0.37
HTR2A P28223 1/20 0.37
HTR7 P34969 1/20 0.37
HTR6 P50406 1/20 0.37
HSD11B1 P28845 1/20 0.36
FLT3 P36888 2/20 0.36
JAK2 O60674 1/20 0.36
SRC P12931 1/20 0.36
CLK1 P49759 1/20 0.36
DYRK1A Q13627 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4481118 1.00 AXL (0.39) AXLGSK3AGSK3BBRAFCYP3A4
SCHEMBL25294215 0.87 LMNA (0.42) AXLGSK3AGSK3BBRAFCYP3A4
SCHEMBL30565980 0.87 LMNA (0.42) AXLGSK3AGSK3BBRAFCYP3A4
SCHEMBL19997224 0.85 AXL (0.42) AXLGSK3AGSK3BBRAFCYP3A4
SCHEMBL31635975 0.84 CDK2 (0.46) AXLGSK3AGSK3BBRAFFLT3
SCHEMBL13888091 0.84 AXL (0.40) AXLCLK1DYRK1A
SCHEMBL1516742 0.84 CDK2 (0.46) AXLGSK3AGSK3BBRAFFLT3
SCHEMBL2814713 0.83 AXL (0.47) AXLGSK3AGSK3BHSD11B1CLK1
SCHEMBL8469861 0.82 AXL (0.39) AXLGSK3BBRAF
SCHEMBL13888085 0.82 PKM (0.47) AXLBRAFFLT3JAK2SRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250361233-A1 Compounds For Activating Serotonin Receptor Psylo Pty Ltd (AU) 2025-11-27 US disclosed
US-12415804-B2 Compounds for activating a serotonin receptor Psylo Pty Ltd (AU) 2025-09-16 US disclosed
US-20250206739-A1 Compounds Psylo Pty Ltd (AU) 2025-06-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250206739-A1 Compounds NLN, SLC18A2, PYGB AXL 4487/4885GSK3A 785/4885GSK3B 691/4885
US-12415804-B2 Compounds for activating a serotonin receptor HTR2C, HTR6, HTR2A AXL 2597/4885GSK3A 821/4885GSK3B 842/4885
US-20250361233-A1 Compounds For Activating Serotonin Receptor HTR2C, HTR2A, HTR6 AXL 2342/4885GSK3A 783/4885GSK3B 797/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.