Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31648311 | 0.86 | ALDH1A1 (0.44) | POLQHRH2HRH3 | |
| SCHEMBL31648183 | 0.82 | ALDH1A1 (0.41) | POLQ | |
| SCHEMBL31648531 | 0.77 | ALDH1A1 (0.46) | POLQ | |
| SCHEMBL31648305 | 0.76 | HRH2 (0.33) | HRH2HRH3 | |
| SCHEMBL31648301 | 0.73 | MAPK1 (0.41) | — | |
| SCHEMBL31648045 | 0.72 | HSP90AA1 (0.44) | POLQ | |
| SCHEMBL31648942 | 0.71 | MEN1 (0.39) | — | |
| SCHEMBL31648798 | 0.71 | MEN1 (0.39) | — | |
| SCHEMBL31648577 | 0.71 | HSP90AA1 (0.36) | POLQ | |
| SCHEMBL26796258 | 0.66 | HRH3 (0.36) | HRH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025132946-A1 | PHENYLPYRROLIDINE DERIVATIVES AND THEIR USE AS POI-THETA DERIVATIVES | BREAKPOINT THERAPEUTICS GMBH (DE) | 2025-06-26 | — | — | WO | disclosed |