Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31649370 | 0.81 | KMT2A (0.43) | POLBTDP1SMN1; SMN2 | |
| SCHEMBL31649412 | 0.81 | KMT2A (0.43) | POLBTDP1SMN1; SMN2 | |
| SCHEMBL31649235 | 0.80 | HTR2A (0.41) | POLB | |
| SCHEMBL31649339 | 0.79 | DPP4 (0.42) | HSD11B1 | |
| SCHEMBL31649429 | 0.79 | CD274 (0.42) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31649062 | 0.76 | ALDH1A1 (0.38) | RAB9ASMN1; SMN2 | |
| SCHEMBL31649393 | 0.74 | TSHR (0.41) | POLBTDP1SMN1; SMN2 | |
| SCHEMBL31649223 | 0.74 | SLC6A2 (0.40) | POLBTDP1SMN1; SMN2 | |
| SCHEMBL31649406 | 0.73 | KMT2A (0.40) | POLBTDP1SMN1; SMN2 | |
| SCHEMBL31649053 | 0.73 | KMT2A (0.40) | POLBTDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025132943-A1 | DECAHYDROQUINOLINES AS DNA POLYMERASE THETA INHIBITORS | BREAKPOINT THERAPEUTICS GMBH (DE) | 2025-06-26 | — | — | WO | claimed |
| WO-2025132943-A1 | DECAHYDROQUINOLINES AS DNA POLYMERASE THETA INHIBITORS | BREAKPOINT THERAPEUTICS GMBH (DE) | 2025-06-26 | — | — | WO | disclosed |