⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31661252 | 0.78 | KDM4E (0.35) | — | |
| SCHEMBL31661363 | 0.74 | KDM4E (0.43) | — | |
| SCHEMBL31661243 | 0.70 | SMN1; SMN2 (0.35) | — | |
| SCHEMBL31661229 | 0.70 | — | — | |
| SCHEMBL14053633 | 0.68 | NPC1 (0.33) | — | |
| SCHEMBL14053249 | 0.68 | PKM (0.58) | — | |
| SCHEMBL6112768 | 0.68 | NPC1 (0.55) | — | |
| Bromide SCHEMBL1204327 | 0.67 | NPC1 (0.32) | — | |
| Bromide SCHEMBL1203281 | 0.67 | PKM (0.56) | — | |
| SCHEMBL12789887 | 0.62 | KDM4E (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025151517-A1 | THIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISORDERS ASSOCIATED WITH MISSFOLDING OF ALPHA-SYNUCLEIN PROTEIN | WAVEBREAK THERAPEUTICS LIMITED (US) | 2025-07-17 | — | — | WO | disclosed |