SCHEMBL31661737

SCHEMBL31661737

N#Cc1c(N)sc2c1CCCC2c1nc(Cc2ccc(-c3cccnc3F)cc2)no1

nearest known ligand 0.32

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CYP11B2 P19099 1/20 0.32
CLPP Q16740 1/20 0.31
CSNK1A1 P48729 1/20 0.31
CSNK1D P48730 1/20 0.31
GSK3B P49841 1/20 0.31
CSNK1G2 P78368 1/20 0.31
NMT1 P30419 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31661569 0.83 CYP11B2 (0.37) CYP11B2
SCHEMBL2648424 0.64 BPTF (0.44)
SCHEMBL31661776 0.57 KRAS (0.36)
SCHEMBL18255822 0.57 CYP11B2 (0.59) CYP11B2CSNK1A1CSNK1DGSK3BCSNK1G2
SCHEMBL12643489 0.56 PLAUR (0.34)
SCHEMBL18255779 0.55 CYP11B2 (0.47) CYP11B2CSNK1A1CSNK1DGSK3BCSNK1G2
SCHEMBL19243902 0.54 CYP11B2 (0.44) CYP11B2GSK3B
SCHEMBL12643259 0.54 BPTF (0.39)
SCHEMBL12643317 0.54 ADORA1 (0.38)
SCHEMBL27785043 0.54 CYP11B2 (0.66) CYP11B2CSNK1A1CSNK1DGSK3BCSNK1G2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025151705-A1 NOVEL INHIBITORS OF DNA DAMAGE REPAIR PATHWAY VRISE THERAPEUTICS, INC. (US) 2025-07-17 WO claimed
WO-2025151705-A1 NOVEL INHIBITORS OF DNA DAMAGE REPAIR PATHWAY VRISE THERAPEUTICS, INC. (US) 2025-07-17 WO disclosed