SCHEMBL31661820

SCHEMBL31661820

NC(=O)c1sccc1-c1ccc(Br)nc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCAT2 O15382 1/20 0.58
CHEK2 O96017 6/20 0.40
CYP19A1 P11511 2/20 0.38
CHEK1 O14757 3/20 0.37
PTGS1 P23219 1/20 0.37
MKNK1 Q9BUB5 2/20 0.36
MKNK2 Q9HBH9 2/20 0.36
TGFBR1 P36897 1/20 0.36
KDR P35968 2/20 0.35
FGFR3 P22607 1/20 0.35
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35
POLB P06746 1/20 0.35
EDNRA P25101 1/20 0.34
RORB Q92753 2/20 0.34
RORC P51449 1/20 0.34
DAPK3 O43293 1/20 0.33
PRKD3 O94806 1/20 0.33
PIM1 P11309 1/20 0.33
PRKACA P17612 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31661900 0.83 BCAT2 (0.57) BCAT2CHEK2CHEK1PTGS1MKNK1
SCHEMBL31661869 0.79 BCAT2 (0.53) BCAT2CHEK2CHEK1PTGS1KDM4E
SCHEMBL31661924 0.78 BCAT2 (0.51) BCAT2CHEK2CHEK1PTGS1TGFBR1
SCHEMBL31661826 0.77 BCAT2 (0.54) BCAT2CHEK2MKNK1MKNK2KDR
SCHEMBL31661908 0.76 BCAT2 (0.53) BCAT2CHEK2CHEK1KDRFGFR3
SCHEMBL6667283 0.75 BCAT2 (0.69) BCAT2CHEK2PTGS1ALDH1A1CDK8
SCHEMBL27353967 0.75 BCAT2 (0.69) BCAT2PTGS1
SCHEMBL2231308 0.75 BCAT2 (0.69) BCAT2PTGS1KDM4EALDH1A1POLB
SCHEMBL6669302 0.74 BCAT2 (0.68) BCAT2CHEK2MKNK1MKNK2ALDH1A1
SCHEMBL4445671 0.74 BCAT2 (1.00) BCAT2PTGS1ALDH1A1RORBMAPK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025151311-A1 NICOTINAMIDE DERIVATIVES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-07-17 WO disclosed