SCHEMBL31662299

SCHEMBL31662299

Cn1cnnc1-c1cc(Oc2ccc(O)cc2)c2cncn2c1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
JAK3 P52333 18/20 0.40
JAK2 O60674 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31662237 0.85 TRIM24 (0.39)
SCHEMBL31662171 0.77 TTK (0.36) JAK3JAK2
SCHEMBL31662245 0.71 CA12 (0.41) JAK3JAK2
SCHEMBL31661980 0.70 SCN9A (0.34) JAK3JAK2
SCHEMBL31662145 0.70 RAB9A (0.39)
SCHEMBL31662191 0.69 HRH3 (0.44)
SCHEMBL2477243 0.69 ALDH1A1 (0.47)
SCHEMBL31662137 0.68 HRH2 (0.42)
SCHEMBL31661973 0.68 TSHR (0.37) JAK3
SCHEMBL22281981 0.64 JAK3 (0.63) JAK3JAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025149545-A1 HETEROARYLPHENYL ETHER DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2025-07-17 WO disclosed