SCHEMBL31667569

SCHEMBL31667569

Cc1cc2[nH]c(=O)oc2cc1CN1C(=O)c2ccccc2C1Cc1ncccc1Br

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.33
▸ PKM P14618 1/20 0.32
▸ PTDSS1 P48651 1/20 0.31
▸ MAPK1 P28482 1/20 0.31
▸ PRMT5 O14744 1/20 0.31
▸ WDR77 Q9BQA1 1/20 0.31
▸ KDM4E B2RXH2 3/20 0.31
▸ L3MBTL1 Q9Y468 1/20 0.31
▸ TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31667139 0.90 PRMT5 (0.34) ALDH1A1PKMPTDSS1MAPK1PRMT5
SCHEMBL31667096 0.86 ALDH1A1 (0.32) ALDH1A1PKMPTDSS1KDM4E
SCHEMBL31667648 0.85 IL4I1 (0.37) ALDH1A1PKMMAPK1PRMT5WDR77
SCHEMBL31667004 0.85 IL4I1 (0.37) ALDH1A1PKMMAPK1PRMT5WDR77
SCHEMBL31667444 0.85 IL4I1 (0.37) ALDH1A1PKMMAPK1PRMT5WDR77
SCHEMBL31667082 0.85 ALDH1A1 (0.36) ALDH1A1PKMPTDSS1MAPK1PRMT5
SCHEMBL31667072 0.83 PTDSS1 (0.34) ALDH1A1PKMPTDSS1MAPK1PRMT5
SCHEMBL31667623 0.80 IL4I1 (0.39) ALDH1A1MAPK1PRMT5WDR77KDM4E
SCHEMBL31667612 0.80 IL4I1 (0.39) ALDH1A1MAPK1PRMT5WDR77KDM4E
SCHEMBL31667349 0.80 IL4I1 (0.39) ALDH1A1MAPK1PRMT5WDR77KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078130-A1 NAMPT MODULATORS, PREPARATIONS, AND USES THEREOF SIRONAX LTD (KY) 2026-03-19 — — US disclosed
EP-4590674-A1 NAMPT MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd (KY) 2025-07-30 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260078130-A1 NAMPT MODULATORS, PREPARATIONS, AND USES THEREOF NAMPT, NNMT, SARM1 ALDH1A1 2719/4885PKM 860/4885PTDSS1 2457/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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