Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 5/20 | 0.50 |
| ▸ | CA2 | P00918 | 5/20 | 0.50 |
| ▸ | CA12 | O43570 | 4/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | CA4 | P22748 | 2/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 4/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8514633 | 0.84 | CA2 (0.59) | CYP19A1CA1CA2CA12CA9 | |
| SCHEMBL92970 | 0.84 | LOXL2 (0.58) | CYP19A1CA1CA2CA12CA9 | |
| SCHEMBL156259 | 0.84 | CA2 (0.67) | CA1CA2CA12CA9CA4 | |
| SCHEMBL3173425 | 0.84 | CYP19A1 (0.51) | CYP19A1CA1CA2CA12CA9 | |
| SCHEMBL3174749 | 0.84 | NAMPT (0.52) | CYP19A1CA1CA2CA12CA9 | |
| SCHEMBL27707919 | 0.82 | LOXL2 (0.56) | CYP19A1CA2CA12CA9CA6 | |
| Hydrogen Sulfide SCHEMBL27473257 | 0.82 | LOXL2 (0.56) | CYP19A1CA2CA12CA9CA6 | |
| SCHEMBL27962507 | 0.80 | MAPT (0.59) | CYP19A1CA1CA2CA12CA9 | |
| SCHEMBL7935644 | 0.79 | CA2 (0.67) | CYP19A1CA1CA2CA12CA9 | |
| Phosphoric Acid SCHEMBL28852152 | 0.79 | LOXL2 (0.48) | CYP19A1CA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101061105-B | Potentiators of glutamate receptors | LILLY CO ELI | 2012-05-30 | — | — | CN | disclosed |
| EP-1817300-B1 | POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2010-03-17 | — | — | EP | disclosed |
| CN-101061105-A | Potentiators of glutamate receptors | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |