SCHEMBL316860

SCHEMBL316860

Cc1cc(C)n2n[c]cc2n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 2/20 0.47
NPC1 O15118 7/20 0.44
RAB9A P51151 7/20 0.44
RECQL P46063 1/20 0.43
KDM4E B2RXH2 9/20 0.42
ALDH1A1 P00352 5/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
HTT P42858 1/20 0.41
MAPT P10636 2/20 0.39
HPGD P15428 1/20 0.38
HCRTR1 O43613 1/20 0.36
CASP3 P42574 1/20 0.36
SENP8 Q96LD8 1/20 0.36
SENP7 Q9BQF6 1/20 0.36
SENP6 Q9GZR1 1/20 0.36
TSHR P16473 2/20 0.36
TP53 P04637 1/20 0.36
POLB P06746 1/20 0.36
GAA P10253 1/20 0.36
HSD17B10 Q99714 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1458756 0.81 ALDH1A1 (0.45) PIK3CGNPC1RAB9AKDM4EALDH1A1
SCHEMBL5270607 0.68 PIK3CG (0.68) PIK3CGNPC1RAB9ARECQLKDM4E
SCHEMBL2491412 0.65 PIK3CG (0.48) PIK3CGNPC1RAB9ARECQLKDM4E
SCHEMBL3460690 0.65 PIK3CG (0.48) PIK3CGNPC1RAB9ARECQLKDM4E
SCHEMBL8822880 0.64 PIK3CG (0.61) PIK3CGNPC1RAB9ARECQLKDM4E
SCHEMBL8801004 0.64 PIK3CG (0.61) PIK3CGNPC1RAB9ARECQLKDM4E
SCHEMBL16104177 0.64 PIK3CG (0.61) PIK3CGNPC1RAB9ARECQLKDM4E
SCHEMBL10002464 0.64 PIK3CG (1.00) PIK3CGNPC1RAB9ARECQLKDM4E
SCHEMBL4151566 0.64 HTR6 (0.31) KDM4EALDH1A1
SCHEMBL15058312 0.64 ALDH1A1 (0.53) PIK3CGNPC1RAB9ARECQLKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3363788-A1 CANNABINOID RECEPTOR MODULATORS Arena Pharmaceuticals, Inc. (US) 2018-08-22 EP claimed
US-20130165412-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2013-06-27 US claimed
US-20120214766-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2012-08-23 US claimed
EP-2470508-A1 CANNABINOID RECEPTOR MODULATORS Arena Pharmaceuticals, Inc. (US) 2012-07-04 EP claimed
WO-2011025541-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. (US) 2011-03-03 WO claimed
US-11771695-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2023-10-03 US disclosed
US-11746091-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2023-09-05 US disclosed
US-20220241274-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2022-08-04 US disclosed
US-11214548-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2022-01-04 US disclosed
US-20210188781-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2021-06-24 US disclosed
US-20210060040-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2021-03-04 US disclosed
US-10632134-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2020-04-28 US disclosed
US-8022091-B2 Triazole derivative TAISHO PHARMACEUTICAL CO., LTD. (JP) 2011-09-20 US disclosed
US-7994204-B2 Binding inhibitor of sphingosine-1-phosphate TAISHO PHARMACEUTICAL CO., LTD (JP) 2011-08-09 US disclosed
WO-2011025541-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. (US) 2011-03-03 WO disclosed
US-20100317652-A1 Compounds Useful In Therapy PFIZER INC 2010-12-16 US disclosed
US-20100041655-A1 TRIAZOLE DERIVATIVE TAISHO PHARMACEUTICAL CO., LTD. (JP) 2010-02-18 US disclosed
US-20090182144-A1 BINDING INHIBITOR OF SPHINGOSINE-1-PHOSPHATE TAISHO PHARMACEUTICAL CO., LTD. (JP) 2009-07-16 US disclosed
EP-1988081-A1 BINDING INHIBITOR OF SPHINGOSINE-1-PHOSPHATE TAISHO PHARMACEUTICAL CO., LTD (JP) 2008-11-05 EP disclosed
EP-1988083-A1 TRIAZOLE DERIVATIVE Taisho Pharmaceutical Co. Ltd. (JP) 2008-11-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120214766-A1 CANNABINOID RECEPTOR MODULATORS CNR1, CNR2, TRPV1 PIK3CG 1450/4885NPC1 558/4885RAB9A 1558/4885
US-10632134-B2 Cannabinoid receptor modulators CNR1, CNR2, GPR18 PIK3CG 384/4885NPC1 927/4885RAB9A 1139/4885
US-20210060040-A1 CANNABINOID RECEPTOR MODULATORS CNR1, CNR2, GPR18 PIK3CG 384/4885NPC1 927/4885RAB9A 1139/4885
US-11746091-B2 Cannabinoid receptor modulators CNR1, CNR2, TRPV1 PIK3CG 1450/4885NPC1 558/4885RAB9A 1558/4885
US-11214548-B2 Cannabinoid receptor modulators CNR1, CNR2, TRPV1 PIK3CG 1450/4885NPC1 558/4885RAB9A 1558/4885
US-20220241274-A1 CANNABINOID RECEPTOR MODULATORS CNR2, CNR1, OPRL1 PIK3CG 662/4885NPC1 1184/4885RAB9A 1386/4885
US-20100041655-A1 TRIAZOLE DERIVATIVE S1PR3, S1PR1, S1PR5 PIK3CG 1104/4885NPC1 958/4885RAB9A 3220/4885
US-20100317652-A1 Compounds Useful In Therapy AVPR1A, AVPR1B, AVPR2 PIK3CG 1375/4885NPC1 3528/4885RAB9A 591/4885
US-20210188781-A1 CANNABINOID RECEPTOR MODULATORS CNR1, CNR2, TRPV1 PIK3CG 1450/4885NPC1 558/4885RAB9A 1558/4885
US-11771695-B2 Cannabinoid receptor modulators CNR2, CNR1, OPRL1 PIK3CG 662/4885NPC1 1184/4885RAB9A 1386/4885
US-20130165412-A1 CANNABINOID RECEPTOR MODULATORS CNR1, CNR2, TRPV1 PIK3CG 1450/4885NPC1 558/4885RAB9A 1558/4885
US-20090182144-A1 BINDING INHIBITOR OF SPHINGOSINE-1-PHOSPHATE S1PR1, S1PR3, S1PR2 PIK3CG 902/4885NPC1 335/4885RAB9A 2826/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.