Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3165629 | 0.92 | GSK3B (0.40) | ADORA3KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL3165286 | 0.87 | USP2 (0.57) | ADORA3KDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL3162603 | 0.87 | GSK3B (0.48) | KDM4EMAPTALDH1A1HPGDMEN1 | |
| SCHEMBL3171564 | 0.86 | CHRM4 (0.45) | ADORA3ALDH1A1TP53MAPK1CHRM4 | |
| SCHEMBL3162796 | 0.84 | ADORA3 (0.53) | ADORA3ALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL3164888 | 0.83 | ADORA3 (0.48) | ADORA3MAPTMEN1KMT2AUSP2 | |
| SCHEMBL3156668 | 0.82 | MAPT (0.59) | MAPTALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL3156575 | 0.81 | ADORA3 (0.48) | ADORA3MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3169692 | 0.80 | ADORA3 (0.47) | ADORA3MAPTALDH1A1KMT2AUSP2 | |
| SCHEMBL3156070 | 0.80 | TSHR (0.54) | ADORA3KDM4EMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |