Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | RAF1 | P04049 | 4/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31705056 | 0.84 | KMO (0.71) | KMO | |
| SCHEMBL31704898 | 0.79 | KMO (0.49) | KMOCNR2MAPK1RAF1BRAF | |
| SCHEMBL25147466 | 0.74 | PIK3CD (0.41) | KMOKDM5BCNR2PIK3CDPIK3CA | |
| SCHEMBL2595624 | 0.74 | KMO (0.40) | KMOKDM5BPIK3CDPIK3CAMAPK1 | |
| Lithium Ion SCHEMBL31704471 | 0.73 | CNR2 (0.40) | KDM5BCNR2PIK3CDPIK3CAMAPK1 | |
| SCHEMBL31704567 | 0.72 | KMO (0.83) | KMO | |
| SCHEMBL28955995 | 0.70 | KMO (0.60) | KMOALDH1A1POLB | |
| SCHEMBL29150579 | 0.70 | KDM5B (0.37) | KMOKDM5BPIK3CDPIK3CAMAPK1 | |
| SCHEMBL23025135 | 0.70 | RET (0.38) | KMOKDM5BPIK3CDPIK3CAMAPK1 | |
| Lithium Ion SCHEMBL31706323 | 0.68 | PIK3CD (0.37) | KMOPIK3CDPIK3CAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |