Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | F12 | P00748 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31706074 | 0.84 | CNR2 (0.41) | CNR2MAPK1RIPK2KDM5BPIK3CD | |
| SCHEMBL31705675 | 0.79 | CNR2 (0.41) | CNR2MAPK1RIPK2ALDH1A1HSD17B10 | |
| Lithium Ion SCHEMBL31705638 | 0.79 | DGAT2 (0.35) | DGAT2ALDH1A1POLBHPGDBLM | |
| Lithium Ion SCHEMBL31706463 | 0.79 | DGAT2 (0.35) | DGAT2ALDH1A1POLBHPGDBLM | |
| Lithium Ion SCHEMBL31704699 | 0.73 | KMO (0.51) | CNR2MAPK1KDM5BPIK3CDPIK3CA | |
| Lithium Ion SCHEMBL31706366 | 0.70 | ALDH1A1 (0.43) | CNR2PIK3CAALDH1A1POLBHPGD | |
| Lithium Ion SCHEMBL31706663 | 0.70 | CYP11B2 (0.42) | MAPK1CYP11B2CYP11B1 | |
| Lithium Ion SCHEMBL31706306 | 0.70 | CYP11B2 (0.42) | MAPK1CYP11B2CYP11B1 | |
| Lithium Ion SCHEMBL31705451 | 0.70 | MAPT (0.40) | CNR2MAPK1KDM5BCHRNA7ALDH1A1 | |
| Lithium Ion SCHEMBL31706584 | 0.70 | MAPT (0.40) | CNR2MAPK1KDM5BCHRNA7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |