Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 9/20 | 0.44 |
| ▸ | KIT | P10721 | 4/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31704866 | 0.84 | NAMPT (0.49) | ALDH1A1SMN1; SMN2ALOX15TSHRGAA | |
| Lithium Ion SCHEMBL31705016 | 0.80 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2ALOX15TSHRGAA | |
| Lithium Ion SCHEMBL31706014 | 0.80 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2ALOX15TSHRGAA | |
| SCHEMBL31706435 | 0.78 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2ALOX15TSHRGAA | |
| Lithium Ion SCHEMBL31705494 | 0.78 | JAK1 (0.44) | ALDH1A1ALOX15TSHRGAAKDM4E | |
| Lithium Ion SCHEMBL31704634 | 0.78 | JAK1 (0.44) | ALDH1A1ALOX15TSHRGAAKDM4E | |
| Lithium Ion SCHEMBL31706302 | 0.76 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2 | |
| Lithium Ion SCHEMBL31705586 | 0.76 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2 | |
| Lithium Ion SCHEMBL31704937 | 0.73 | TLR9 (0.46) | ALDH1A1MAPK1 | |
| Lithium Ion SCHEMBL31704941 | 0.73 | TDP1 (0.51) | ALDH1A1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |