Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.33 |
| ▸ | BTK | Q06187 | 4/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | QDPR | P09417 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31705586 | 1.00 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2ATROPRM1BTK | |
| SCHEMBL31706770 | 0.88 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2ATRBTKSOS1 | |
| Lithium Ion SCHEMBL31704782 | 0.88 | TBK1 (0.35) | ALDH1A1SMN1; SMN2OPRM1 | |
| Lithium Ion SCHEMBL31705265 | 0.88 | TBK1 (0.35) | ALDH1A1SMN1; SMN2OPRM1 | |
| SCHEMBL31705531 | 0.84 | CCNT1 (0.38) | ALDH1A1SMN1; SMN2ATROPRM1SOS1 | |
| Lithium Ion SCHEMBL31704957 | 0.83 | OPRM1 (0.34) | OPRM1 | |
| Lithium Ion SCHEMBL31704679 | 0.83 | OPRM1 (0.34) | OPRM1 | |
| Lithium Ion SCHEMBL31705308 | 0.76 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2 | |
| Lithium Ion SCHEMBL31704606 | 0.73 | PIK3CD (0.44) | — | |
| Lithium Ion SCHEMBL31705859 | 0.73 | PIK3CD (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |