Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31704955 | 0.92 | NAMPT (0.47) | CHRNB2CHRNA4TDP1NAMPTALDH1A1 | |
| Lithium Ion SCHEMBL31706521 | 0.92 | NAMPT (0.47) | CHRNB2CHRNA4TDP1NAMPTALDH1A1 | |
| Lithium Ion SCHEMBL31706878 | 0.88 | TDP1 (0.50) | CHRNB2CHRNA4TDP1NAMPTALDH1A1 | |
| Lithium Ion SCHEMBL31704582 | 0.88 | TDP1 (0.50) | CHRNB2CHRNA4TDP1NAMPTALDH1A1 | |
| SCHEMBL31705168 | 0.83 | ATM (0.43) | CHRNB2CHRNA4TDP1NAMPTALDH1A1 | |
| Lithium Ion SCHEMBL31705412 | 0.81 | CHRNB2 (0.37) | CHRNB2CHRNA4ALDH1A1MAPTSMN1; SMN2 | |
| Lithium Ion SCHEMBL31705364 | 0.81 | CHRNB2 (0.37) | CHRNB2CHRNA4ALDH1A1MAPTSMN1; SMN2 | |
| Lithium Ion SCHEMBL31705607 | 0.80 | PLOD2 (0.48) | CHRNB2CHRNA4ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL31705602 | 0.79 | NAMPT (0.48) | CHRNB2CHRNA4TDP1NAMPTALDH1A1 | |
| Lithium Ion SCHEMBL31705497 | 0.79 | NAMPT (0.39) | NAMPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |