Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | LSS | P48449 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31706878 | 1.00 | TDP1 (0.50) | TDP1MAPTALDH1A1KMT2AMEN1 | |
| Lithium Ion SCHEMBL31706365 | 0.88 | CHRNB2 (0.41) | TDP1MAPTALDH1A1KMT2AMEN1 | |
| Lithium Ion SCHEMBL31706521 | 0.88 | NAMPT (0.47) | TDP1MAPTALDH1A1KMT2AMEN1 | |
| Lithium Ion SCHEMBL31704955 | 0.88 | NAMPT (0.47) | TDP1MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL31706677 | 0.86 | TDP1 (0.52) | TDP1MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL31705087 | 0.82 | TDP1 (0.48) | TDP1MAPTALDH1A1KMT2AMEN1 | |
| Lithium Ion SCHEMBL31706665 | 0.78 | HTR2B (0.40) | TDP1ALDH1A1CHRNB2CHRNA4POLB | |
| Lithium Ion SCHEMBL31706216 | 0.78 | HTR2B (0.40) | TDP1ALDH1A1CHRNB2CHRNA4POLB | |
| Lithium Ion SCHEMBL31705607 | 0.77 | PLOD2 (0.48) | MAPTALDH1A1CHRNB2CHRNA4POLB | |
| Lithium Ion SCHEMBL31705050 | 0.75 | CHRNB2 (0.42) | MAPTALDH1A1CHRNB2CHRNA4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |