Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.36 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.36 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31705364 | 1.00 | CHRNB2 (0.37) | CHRNB2CHRNA4PLOD2PLOD3PLOD1 | |
| SCHEMBL31706095 | 0.88 | CHRNB2 (0.38) | CHRNB2CHRNA4PLOD2PLOD3PLOD1 | |
| SCHEMBL31705614 | 0.84 | ATM (0.41) | PLOD2PLOD3PLOD1BRAFALDH1A1 | |
| Lithium Ion SCHEMBL31706622 | 0.82 | BRAF (0.39) | CHRNB2CHRNA4PLOD2PLOD3PLOD1 | |
| Lithium Ion SCHEMBL31706826 | 0.82 | BRAF (0.39) | CHRNB2CHRNA4PLOD2PLOD3PLOD1 | |
| Lithium Ion SCHEMBL31706760 | 0.82 | BRAF (0.39) | CHRNB2CHRNA4PLOD2PLOD3PLOD1 | |
| Lithium Ion SCHEMBL31705985 | 0.82 | BRAF (0.39) | CHRNB2CHRNA4PLOD2PLOD3PLOD1 | |
| Lithium Ion SCHEMBL31706365 | 0.81 | CHRNB2 (0.41) | CHRNB2CHRNA4ALDH1A1LMNAMAPT | |
| Lithium Ion SCHEMBL31705607 | 0.78 | PLOD2 (0.48) | CHRNB2CHRNA4PLOD2PLOD3PLOD1 | |
| Lithium Ion SCHEMBL31706297 | 0.76 | CASP1 (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |