Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31706306 | 1.00 | CYP11B2 (0.42) | CYP11B2CYP11B1MAPK1HDAC3HDAC1 | |
| SCHEMBL31705330 | 0.84 | CYP11B2 (0.46) | CYP11B2CYP11B1MAPK1SERPINE1 | |
| SCHEMBL30678406 | 0.83 | CYP11B2 (0.51) | CYP11B2CYP11B1MAPK1HDAC3HDAC1 | |
| SCHEMBL31705854 | 0.79 | ATM (0.50) | CYP11B2CYP11B1MAPK1 | |
| SCHEMBL31704913 | 0.79 | ATM (0.50) | CYP11B2CYP11B1MAPK1 | |
| Lithium Ion SCHEMBL31706119 | 0.79 | NAMPT (0.39) | CYP11B2NAMPT | |
| Lithium Ion SCHEMBL31705497 | 0.79 | NAMPT (0.39) | CYP11B2NAMPT | |
| Lithium Ion SCHEMBL31706665 | 0.77 | HTR2B (0.40) | CYP11B2NAMPTDGAT1 | |
| Lithium Ion SCHEMBL31706216 | 0.77 | HTR2B (0.40) | CYP11B2NAMPTDGAT1 | |
| SCHEMBL17686094 | 0.74 | CYP11B2 (0.41) | CYP11B2CYP11B1MAPK1SERPINE1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |