Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 10/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31705497 | 1.00 | NAMPT (0.39) | NAMPTLMNATLR9TLR8TLR7 | |
| Lithium Ion SCHEMBL31706216 | 0.90 | HTR2B (0.40) | NAMPTLMNATLR9TLR8TLR7 | |
| Lithium Ion SCHEMBL31706665 | 0.90 | HTR2B (0.40) | NAMPTLMNATLR9TLR8TLR7 | |
| SCHEMBL31706109 | 0.88 | NAMPT (0.40) | NAMPTLMNATLR9TLR8TLR7 | |
| Lithium Ion SCHEMBL31705499 | 0.87 | NAMPT (0.40) | NAMPTTLR9TLR8TLR7TNKS | |
| SCHEMBL31706230 | 0.83 | ATM (0.42) | NAMPTLMNACYP11B2 | |
| Lithium Ion SCHEMBL31706365 | 0.79 | CHRNB2 (0.41) | NAMPTLMNA | |
| Lithium Ion SCHEMBL31706306 | 0.79 | CYP11B2 (0.42) | NAMPTCYP11B2 | |
| Lithium Ion SCHEMBL31706663 | 0.79 | CYP11B2 (0.42) | NAMPTCYP11B2 | |
| SCHEMBL31705199 | 0.77 | NAMPT (0.41) | NAMPTTLR9TLR8TLR7TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |