Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31706216 | 1.00 | HTR2B (0.40) | HTR2BLMNAHPGDALDH1A1CNR1 | |
| Lithium Ion SCHEMBL31706119 | 0.90 | NAMPT (0.39) | HTR2BLMNANAMPTCYP11B2TLR9 | |
| Lithium Ion SCHEMBL31705497 | 0.90 | NAMPT (0.39) | HTR2BLMNANAMPTCYP11B2TLR9 | |
| SCHEMBL31706383 | 0.86 | HTR2B (0.44) | HTR2BLMNAHPGDALDH1A1CNR1 | |
| SCHEMBL31706262 | 0.82 | ATM (0.46) | HTR2BLMNAALDH1A1SMN1; SMN2GAA | |
| Lithium Ion SCHEMBL31706048 | 0.81 | HTR2B (0.45) | HTR2BALDH1A1CNR1CYP3A4CYP2D6 | |
| Lithium Ion SCHEMBL31704582 | 0.78 | TDP1 (0.50) | ALDH1A1POLBSMN1; SMN2NAMPTCHRNB2 | |
| Lithium Ion SCHEMBL31706878 | 0.78 | TDP1 (0.50) | ALDH1A1POLBSMN1; SMN2NAMPTCHRNB2 | |
| Lithium Ion SCHEMBL31706306 | 0.77 | CYP11B2 (0.42) | NAMPTCYP11B2DGAT1 | |
| Lithium Ion SCHEMBL31706663 | 0.77 | CYP11B2 (0.42) | NAMPTCYP11B2DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |