Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.35 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.35 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.35 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.35 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31705985 | 1.00 | BRAF (0.39) | BRAFCHRNB2CHRNA4ALDH1A1PLOD2 | |
| Lithium Ion SCHEMBL31706622 | 1.00 | BRAF (0.39) | BRAFCHRNB2CHRNA4ALDH1A1PLOD2 | |
| Lithium Ion SCHEMBL31706826 | 1.00 | BRAF (0.39) | BRAFCHRNB2CHRNA4ALDH1A1PLOD2 | |
| SCHEMBL31704987 | 0.88 | BRAF (0.40) | BRAFCHRNB2CHRNA4ALDH1A1PLOD2 | |
| SCHEMBL31706644 | 0.84 | BRAF (0.41) | BRAFALDH1A1PLOD2PLOD3PLOD1 | |
| SCHEMBL31705568 | 0.84 | BRAF (0.41) | BRAFALDH1A1PLOD2PLOD3PLOD1 | |
| Lithium Ion SCHEMBL31705412 | 0.82 | CHRNB2 (0.37) | BRAFCHRNB2CHRNA4ALDH1A1PLOD2 | |
| Lithium Ion SCHEMBL31705364 | 0.82 | CHRNB2 (0.37) | BRAFCHRNB2CHRNA4ALDH1A1PLOD2 | |
| Lithium Ion SCHEMBL31705607 | 0.77 | PLOD2 (0.48) | CHRNB2CHRNA4ALDH1A1PLOD2PLOD3 | |
| Lithium Ion SCHEMBL31704582 | 0.75 | TDP1 (0.50) | CHRNB2CHRNA4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |