Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | TGFB1 | P01137 | 1/20 | 0.36 |
| ▸ | GNG2 | P59768 | 1/20 | 0.35 |
| ▸ | GNB1 | P62873 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29685869 | 0.82 | IP6K1 (0.39) | NNMTSMN1; SMN2HPGDIP6K1PDE5A | |
| SCHEMBL26918319 | 0.82 | IP6K1 (0.39) | NNMTSMN1; SMN2HPGDIP6K1PDE5A | |
| SCHEMBL31712852 | 0.81 | IP6K1 (0.36) | NNMTSMN1; SMN2HPGDIP6K1PDE5A | |
| SCHEMBL31712859 | 0.79 | NNMT (0.48) | NNMTSMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL31712899 | 0.78 | SIRT6 (0.37) | NNMTSMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL31712857 | 0.76 | TSHR (0.42) | NNMTSMN1; SMN2IP6K1PDE5ACHEK2 | |
| SCHEMBL9097938 | 0.74 | ACHE (0.48) | HPGDALDH1A1 | |
| SCHEMBL31425752 | 0.74 | RET (0.41) | RAB9ANPC1HPGDCYP11B2ALDH1A1 | |
| SCHEMBL29106210 | 0.72 | IP6K1 (0.38) | NNMTIP6K1PDE5ACHEK2TGFB1 | |
| SCHEMBL9096010 | 0.71 | GLA (0.46) | MAPTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4251624-B1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC (US) | 2025-10-29 | — | — | EP | claimed |