Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.39 |
| ▸ | NNMT | P40261 | 3/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31712880 | 0.79 | PARP1 (0.39) | TSHRPARP1NNMTCHEK1PDE4B | |
| SCHEMBL31712852 | 0.77 | IP6K1 (0.36) | TSHRPDE5AIP6K1NNMTCHEK2 | |
| SCHEMBL31712871 | 0.76 | NNMT (0.40) | PDE5AIP6K1NNMTCHEK2SMN1; SMN2 | |
| SCHEMBL29685869 | 0.75 | IP6K1 (0.39) | TSHRPARP1PDE5AIP6K1NNMT | |
| SCHEMBL26918319 | 0.75 | IP6K1 (0.39) | TSHRPARP1PDE5AIP6K1NNMT | |
| SCHEMBL30427718 | 0.68 | NNMT (0.51) | TSHRPARP1NNMTCHEK2CHEK1 | |
| SCHEMBL6282473 | 0.68 | NNMT (0.51) | TSHRPARP1NNMTCHEK2CHEK1 | |
| SCHEMBL31712865 | 0.68 | IP6K1 (0.42) | PDE5AIP6K1NNMTCHEK2APP | |
| SCHEMBL29503137 | 0.67 | PRKCI (0.69) | TSHRPRKCI | |
| SCHEMBL4320180 | 0.67 | TSHR (0.68) | TSHRPARP1SMN1; SMN2PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4251624-B1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC (US) | 2025-10-29 | — | — | EP | claimed |